Inpp4a^tm2.2Tsak
Targeted Allele Detail

Summary

• Symbol: Inpp4a^tm2.2Tsak
• Name: inositol polyphosphate-4-phosphatase, type I; targeted mutation 2.2, Takehiko Sasaki
• MGI ID: MGI:7520502
• Synonyms: Inpp4a^deltaEx23
• Gene: Inpp4a Location: Chr1:37338946-37449817 bp, + strand Genetic Position: Chr1, 15.46 cM
• Alliance: Inpp4a^tm2.2Tsak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339153
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Two loxP sites were introduced into intron 22 and one site was introduced into intron 23. A LacZ-PGK-Neomycin resistance selection cassette was inserted in an antisense orientation to Inpp4a transcription between the two lox sites in intron 22. The selection cassette and exon 23 were subsequently removed in the germline via Cre-mediated recombination. (J:339153)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inpp4a Mutation: 53 strains or lines available

References

• Original: J:339153 Tran DM, et al., Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity. Dis Model Mech. 2023 Jul 1;16(7)
• All: 1 reference(s)