Inpp4a^tm2.1Tsak
Targeted Allele Detail

Summary

• Symbol: Inpp4a^tm2.1Tsak
• Name: inositol polyphosphate-4-phosphatase, type I; targeted mutation 2.1, Takehiko Sasaki
• MGI ID: MGI:7520501
• Synonyms: Inpp4a^flox
• Gene: Inpp4a Location: Chr1:37338946-37449817 bp, + strand Genetic Position: Chr1, 15.46 cM
• Alliance: Inpp4a^tm2.1Tsak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339154
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Two loxP sites were introduced into intron 22 and one site was introduced into intron 23. A LacZ-PGK-Neomycin resistance selection cassette was inserted in an antisense orientation to Inpp4a transcription between the two lox sites in intron 22. The selection cassette was subsequently removed in the germline via Cre-mediated recombination. (J:339154)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inpp4a Mutation: 53 strains or lines available

References

• Original: J:339154 Morioka S, et al., Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model. Innate Immun. 2016 Aug;22(6):444-51
• All: 3 reference(s)