Khk^tm2.1Stf
Targeted Allele Detail

Summary

• Symbol: Khk^tm2.1Stf
• Name: ketohexokinase; targeted mutation 2.1, Markus Stoffel
• MGI ID: MGI:7520425
• Synonyms: KhkC^flox
• Gene: Khk Location: Chr5:31078780-31088592 bp, + strand Genetic Position: Chr5, 16.9 cM
• Alliance: Khk^tm2.1Stf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338902
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A 499bp region (chr5:31,084,234-31,084,732 mm39) encompassing exon 3c was flanked with loxP sites. The FRT-flanked neo cassette was inserted along with the 3' loxP site. The neomycin selection cassette was subsequently removed in the germline via FLP-mediated recombination. (J:338902)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Khk Mutation: 25 strains or lines available

References

• Original: J:338902 Guccini I, et al., Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development. iScience. 2023 Aug 18;26(8):107368
• All: 1 reference(s)