Pik3c3^tm1.1Rhrs
Targeted Allele Detail

Summary

• Symbol: Pik3c3^tm1.1Rhrs
• Name: phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1.1, Raymond Harris
• MGI ID: MGI:7520370
• Synonyms: mVps34^flox
• Gene: Pik3c3 Location: Chr18:30405800-30481179 bp, + strand Genetic Position: Chr18, 17.41 cM
• Alliance: Pik3c3^tm1.1Rhrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339066
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked PGK-neomycin selection cassette and a loxP site were inserted upstream of exon 20 and a second loxP site was inserted downstream of exon 21. The selection cassette was removed via flp-mediated recombination leaving exons 20-21 floxed. (J:339066)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3c3 Mutation: 48 strains or lines available

References

• Original: J:339066 Chen J, et al., mVps34 deletion in podocytes causes glomerulosclerosis by disrupting intracellular vesicle trafficking. J Am Soc Nephrol. 2013 Feb;24(2):198-207
• All: 1 reference(s)