Gorab^tm1.1Uko
Targeted Allele Detail

Summary

• Symbol: Gorab^tm1.1Uko
• Name: golgin, RAB6-interacting; targeted mutation 1.1, Uwe Kornak
• MGI ID: MGI:7520329
• Synonyms: Gorab^flox
• Gene: Gorab Location: Chr1:163212477-163231238 bp, - strand Genetic Position: Chr1, 70.67 cM
• Alliance: Gorab^tm1.1Uko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261043
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted upstream of exon 2 and an frt-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 4. The neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:261043)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gorab Mutation: 23 strains or lines available

References

• Original: J:261043 Chan WL, et al., Impaired proteoglycan glycosylation, elevated TGF-beta signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. PLoS Genet. 2018 Mar;14(3):e1007242
• All: 3 reference(s)