Lnx2^tm1.1Pyng
Targeted Allele Detail

Summary

• Symbol: Lnx2^tm1.1Pyng
• Name: ligand of numb-protein X 2; targeted mutation 1.1 Paul Young
• MGI ID: MGI:7520108
• Synonyms: Lnx2 - KO
• Gene: Lnx2 Location: Chr5:146953471-147013364 bp, - strand Genetic Position: Chr5, 86.69 cM, cytoband G2
• Alliance: Lnx2^tm1.1Pyng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339039
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin resistance gene was inserted upstream of exon 2, and a third loxP site was inserted downstream of exon 2. Cre-mediated recombination resulted in the deletion of the selection cassette and exon 2. (J:339039)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lnx2 Mutation: 84 strains or lines available

References

• Original: J:339039 Lenihan JA, et al., Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Mol Neurobiol. 2017 Dec;54(10):8090-8109
• All: 1 reference(s)