Vax1^em1Jkm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Vax1^em1Jkm
• Name: ventral anterior homeobox 1; endonuclease-mediated mutation 1, Jin Woo Kim
• MGI ID: MGI:7518961
• Synonyms: Vax1^AA
• Gene: Vax1 Location: Chr19:59154619-59158488 bp, - strand Genetic Position: Chr19, 54.61 cM
• Alliance: Vax1^em1Jkm page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a lysine to alanine substitution at amino acid 101 and an arginine to alanine substitution at amino acid 102 (KR to AA) in exon 2. This AA mutation disrupts the GAG sugar-binding motif of Vax1 and generates an intercellular transfer (from optic stalk cells to retinal ganglion cell axons)-defective protein . (J:333797)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vax1 Mutation: 13 strains or lines available

References

• Original: J:333797 Min KW, et al., Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant. Exp Mol Med. 2023 Feb;55(2):385-400
• All: 1 reference(s)