Gsdme^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gsdme^em1Cya
• Name: gasdermin E; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7518710
• Gene: Gsdme Location: Chr6:50167013-50240837 bp, - strand Genetic Position: Chr6, 24.13 cM
• Alliance: Gsdme^em1Cya page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a knock-out allele. (J:338928)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdme Mutation: 38 strains or lines available

References

• Original: J:338928 Luo X, et al., Cyclophosphamide induced intestinal injury is alleviated by blocking the TLR9/caspase3/GSDME mediated intestinal epithelium pyroptosis. Int Immunopharmacol. 2023 May 1;119:110244
• All: 1 reference(s)