Nobox^em1Stpg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nobox^em1Stpg
• Name: NOBOX oogenesis homeobox; endonuclease-mediated mutation 1, Stephanie A Pangas
• MGI ID: MGI:7518656
• Synonyms: Nobox^G403A
• Gene: Nobox Location: Chr6:43280608-43286488 bp, - strand Genetic Position: Chr6, 21.17 cM
• Alliance: Nobox^em1Stpg page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: Lysine codon 125 (AAG) in exon 3 was changed to arginine (AGG) (c.374A>G, p.K125R) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation blocks sumoylation of the affected residue in the encoded peptide. (J:338751)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nobox Mutation: 26 strains or lines available

References

• Original: J:338751 Patton BK, et al., Sumoylation regulates functional properties of the oocyte transcription factors SOHLH1 and NOBOX. FASEB J. 2023 Feb;37(2):e22747
• All: 1 reference(s)