Rab10^tm1.2Emsz
Targeted Allele Detail

Summary

• Symbol: Rab10^tm1.2Emsz
• Name: RAB10, member RAS oncogene family; targeted mutation 1.2, Erzsebet M Szatmari
• MGI ID: MGI:7518597
• Gene: Rab10 Location: Chr12:3297428-3359969 bp, - strand Genetic Position: Chr12, 1.71 cM
• Alliance: Rab10^tm1.2Emsz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338919
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A FRT-flanked neomycin selection cassette and a loxP site were inserted 265 bp upstream of exon 2 and a second loxP site was inserted 169 bp downstream of exon 2. The neomycin selection cassette was removed via flp-mediated recombination. Exon 2 was deleted via cre-mediated recombination. (J:338919)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab10 Mutation: 28 strains or lines available

References

• Original: J:338919 Bunner W, et al., Behavioral and Transcriptome Profiling of Heterozygous Rab10 Knock-Out Mice. eNeuro. 2023 May;10(5):ENEURO.0459-22.2023
• All: 1 reference(s)