Apoe^{tm4207.1(APOE_i4)Xen}
Targeted Allele Detail

Summary

• Symbol: Apoe^{tm4207.1(APOE_i4)Xen}
• Name: apolipoprotein E; targeted mutation 4207.1, Taconic Biosciences
• MGI ID: MGI:7518244
• Synonyms: Apoe^{tm4207.1(APOE*R130, *R176)}
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^{tm4207.1(APOE_i4)Xen} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338907
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The human isoform 4 of the APOE gene (containing arginine at residues 130 and 176) was inserted and most likely replaced some of the endogenous sequence, however this information is not provided. (J:338907)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 163 strains or lines available

References

• Original: J:338907 Mattar JM, et al., Sex Differences in Metabolic Indices and Chronic Neuroinflammation in Response to Prolonged High-Fat Diet in ApoE4 Knock-In Mice. Int J Mol Sci. 2022 Apr 1;23(7)
• All: 1 reference(s)