Foxo1^tm1Zzhu
Targeted Allele Detail

Summary

• Symbol: Foxo1^tm1Zzhu
• Name: forkhead box O1; targeted mutation 1, Zilu Zhu
• MGI ID: MGI:7516132
• Synonyms: Foxo1^T24A
• Gene: Foxo1 Location: Chr3:52175758-52257530 bp, + strand Genetic Position: Chr3, 23.19 cM
• Alliance: Foxo1^tm1Zzhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287219
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A loxP site, a Foxo1 cDNA, a roxP site, a second loxP site, and poly(A) signal sequence, were inserted into the 5' UTR of a mutated exon 1. The mutation involved changing threonine codon 24 (ACC) to alanine (p.T24A). This allele expresses the wild-type transcript, but after Cre-mediated deletion of the cDNA sequence it expresses the mutated transcript. The mutation changes a phosphorylatable residue in the encoded peptide to a phosphoblocker, which blocks the inactivation of the protein. (J:287219)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxo1 Mutation: 31 strains or lines available

References

• Original: J:287219 Zhu Z, et al., The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response. Life Sci Alliance. 2019 Dec;2(6)
• All: 2 reference(s)