Foxp3^tm1.1Jand
Targeted Allele Detail

Summary

• Symbol: Foxp3^tm1.1Jand
• Name: forkhead box P3; targeted mutation 1.1, John Andersson
• MGI ID: MGI:7515019
• Synonyms: Foxp3delta2delta7
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^tm1.1Jand page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338777
• Parent Cell Line: BAC-BA1 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S/SvEv)F1

Mutation description

• Allele Type: Targeted (Modified isoform(s), Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was constructed such that a Foxp3 cDNA lacking exons 2 and 7 was inserted at the translation initiation ATG codon of Foxp3 and the TGA stop of Foxp3 was replaced by a 2A peptide-GFP cassette followed by a double polyadenylation signal (pA) and an FRT-flanked neomycin cassette. The neomycin cassette was removed via flp-mediated recombination. (J:338777)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 57 strains or lines available

References

• Original: J:338777 Joly AL, et al., Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo. J Autoimmun. 2015 Sep;63:23-30
• All: 1 reference(s)