Ltc4s^tm1.1Jabo
Targeted Allele Detail

Summary

• Symbol: Ltc4s^tm1.1Jabo
• Name: leukotriene C4 synthase; targeted mutation 1.1, Joshua Boyce
• MGI ID: MGI:7514604
• Synonyms: Ltc4s^fl
• Gene: Ltc4s Location: Chr11:50127288-50129378 bp, - strand Genetic Position: Chr11, 30.4 cM, cytoband B1.1-B1.2
• Alliance: Ltc4s^tm1.1Jabo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338728
• Parent Cell Line: iTL BF1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserte flanking the 1st exon of the gene. An frt-flanked neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:338728)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ltc4s Mutation: 13 strains or lines available

References

• Original: J:338728 Ualiyeva S, et al., Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation. Sci Immunol. 2021 Dec 24;6(66):eabj0474
• All: 1 reference(s)