Adar^em1Crwy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adar^em1Crwy
• Name: adenosine deaminase, RNA-specific; endonuclease-mediated mutation 1, Carl R Walkley
• MGI ID: MGI:7514376
• Synonyms: Adar1^P195A
• Gene: Adar Location: Chr3:89622329-89660753 bp, + strand Genetic Position: Chr3, 39.19 cM, cytoband F2
• Alliance: Adar^em1Crwy page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: Proline codon 195 (CCT) in exon 2 was changed to alanine (GCT) (p.P195A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. This mutation is the equivalent of the human p.P193A mutation associated with AicardiGoutieres Syndrome (AGS). (J:338600)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adar Mutation: 71 strains or lines available

References

• Original: J:338600 Liang Z, et al., The phenotype of the most common human ADAR1p150 Zalpha mutation P193A in mice is partially penetrant. EMBO Rep. 2023 May 4;24(5):e55835
• All: 2 reference(s)