Ntn5^tm1.2Ksak
Targeted Allele Detail

Summary

• Symbol: Ntn5^tm1.2Ksak
• Name: netrin 5; targeted mutation 1.2, Kenji Sakimura
• MGI ID: MGI:7514354
• Synonyms: NTN5 KO
• Gene: Ntn5 Location: Chr7:45333519-45343980 bp, + strand Genetic Position: Chr7, 29.43 cM
• Alliance: Ntn5^tm1.2Ksak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:337268
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Two LoxP sequences were inserted to flank a 2.5 kb region containing exons 5 and 6, including the C-terminal coding sequence and 3 UTR. An frt-flanked pgk-neo cassette was also inserted in front of the loxP sequence on the 3 side, and was subsequently removed via FLP-mediated recombination in the germline. Further Cre-mediated recombination in the germline removed the 2.5 kb region containing exons 5 and 6. (J:337268)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntn5 Mutation: 12 strains or lines available

References

• Original: J:337268 Ikegaya S, et al., Decreased Proliferation in the Neurogenic Niche, Disorganized Neuroblast Migration, and Increased Oligodendrogenesis in Adult Netrin-5-Deficient Mice. Front Neurosci. 2020;14:570974
• All: 1 reference(s)