Nfe2l2^tm1Abk
Targeted Allele Detail

Summary

• Symbol: Nfe2l2^tm1Abk
• Name: nuclear factor, erythroid derived 2, like 2; targeted mutation 1, Annadora Bruce-Keller
• MGI ID: MGI:7514042
• Synonyms: RT-Nrf2^flox
• Gene: Nfe2l2 Location: Chr2:75505857-75534985 bp, - strand Genetic Position: Chr2, 44.75 cM
• Alliance: Nfe2l2^tm1Abk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240623
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A flippase recombinase target (FRT)-flanked region containing the LacZ beta-Galactosidase and Neomycin expression genes and a LoxP-flanked region containing exons 4 and 5 was inserted into the gene. The targeting vectors PRPGS00171_A_H03 used to generate Nrf2-knockout mice were purchased from the International Knockout Mouse Consortium (project KOMP-CSD 298710). (J:240623)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfe2l2 Mutation: 94 strains or lines available

References

• Original: J:240623 Zhang L, et al., Adipose-specific ablation of Nrf2 transiently delayed high-fat diet-induced obesity by altering glucose, lipid and energy metabolism of male mice. Am J Transl Res. 2016;8(12):5309-5319
• All: 1 reference(s)