Mafb^tm1.1Mari
Targeted Allele Detail

Summary

• Symbol: Mafb^tm1.1Mari
• Name: MAF bZIP transcription factor B; targeted mutation 1.1, Thomas Marichal
• MGI ID: MGI:7513906
• Synonyms: Mafb^fl
• Gene: Mafb Location: Chr2:160205623-160208985 bp, - strand Genetic Position: Chr2, 80.92 cM
• Alliance: Mafb^tm1.1Mari page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338559
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Using recombination-mediated genetic engineering, a loxP-EM7-Neo-loxP ligated to Mafb 5' segment and an FRT-Neo-FRT-loxP ligated to Mafb 3' segments were introduced into mouse embryonic stem cells. Successfully recombined clones were injected into blastocysts to make loxP-flanked Mafb-Neo mice and crossed to the FLP-expressing line to remove the Pgk-Neo cassette. (J:338559)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mafb Mutation: 20 strains or lines available

References

• Original: J:338559 Vanneste D, et al., MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation. Nat Immunol. 2023 May;24(5):827-840
• All: 2 reference(s)