Lyn^em2Fret
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lyn^em2Fret
• Name: Lyn proto-oncogene, Src family tyrosine kinase; endonuclease-mediated mutation 2, Tanya S Freedman
• MGI ID: MGI:7513895
• Synonyms: LynB^KO
• Gene: Lyn Location: Chr4:3676865-3791613 bp, + strand Genetic Position: Chr4, 2.05 cM
• Alliance: Lyn^em2Fret page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9-mediated recombination using a single guide RNA targeted at the LynB isoform splice site in exon 2 inserted two single nucleotide substitutions ablating the splice site. (J:338556)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lyn Mutation: 67 strains or lines available

References

• Original: J:338556 Brian BF 4th, et al., A dominant function of LynB kinase in preventing autoimmunity. Sci Adv. 2022 Apr 22;8(16):eabj5227
• All: 1 reference(s)