Eif4ebp1^tm2.1Cvp
Targeted Allele Detail

Summary

• Symbol: Eif4ebp1^tm2.1Cvp
• Name: eukaryotic translation initiation factor 4E binding protein 1; targeted mutation 2.1, Patrick Moore
• MGI ID: MGI:7512960
• Synonyms: 4E-BP1^S82D
• Gene: Eif4ebp1 Location: Chr8:27750355-27765684 bp, + strand Genetic Position: Chr8, 15.95 cM, cytoband A4-B1
• Alliance: Eif4ebp1^tm2.1Cvp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338489
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: An AGC to GAC change resulting in a serine to aspartate substitution at amino acid 82 (p.S82D) was introduced in exon 2. A loxP-flanked neomycin selection cassette was inserted upstream of exon 2 and removed via cre-mediated recombination. This change results in a phospho-mimetic mutation mimicking constitutive CDK1 phosphorylation. (J:338489)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Eif4ebp1 Mutation: 33 strains or lines available

References

• Original: J:338489 Cao S, et al., Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice. PLoS One. 2023;18(3):e0282914
• All: 1 reference(s)