Tg(Dmp1-SOST)#Alegr
Transgene Detail

Summary

• Symbol: Tg(Dmp1-SOST)#Alegr
• Name: transgene insertion, Alexander G Robling
• MGI ID: MGI:7512802
• Synonyms: ^8kbDmp1-hSOST
• Transgene: Tg(Dmp1-SOST)#Alegr Location: unknown
• Alliance: Tg(Dmp1-SOST)#Alegr page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Dmp1-SOST)#Alegr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOST (50964)

  Sost	(MGI:1921749)

• Tg(Dmp1-SOST)#Alegr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dmp1 (MGI:94910)

• Mutation details: A 12 kb DNA fragment containing 8 kb of the 5'flanking region, exon 1, intron 1, and 17 bp of exon 2 of mouse Dmp1 was used to drive expression of a human SOST cDNA. (J:305286)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:305286 Bullock WA, et al., Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo. iScience. 2019 Oct 25;20:205-215
• All: 1 reference(s)