Hacd2^tm1.1Chey
Targeted Allele Detail

Summary

• Symbol: Hacd2^tm1.1Chey
• Name: 3-hydroxyacyl-CoA dehydratase 2; targeted mutation 1.1, Yong Q Chen
• MGI ID: MGI:7511866
• Synonyms: Hacd2^flox
• Gene: Hacd2 Location: Chr16:34842798-34929547 bp, + strand Genetic Position: Chr16, 24.54 cM
• Alliance: Hacd2^tm1.1Chey page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338350
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a self-deletion anchor flanked neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. The neo cassette was deleted after insertion. (J:338350)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hacd2 Mutation: 16 strains or lines available

References

• Original: J:338350 Wei L, et al., 3-Hydroxyacyl-CoA dehydratase 2 deficiency confers resistance to diet-induced obesity and glucose intolerance. Biochem Biophys Res Commun. 2022 May 21;605:134-140
• All: 2 reference(s)