Taf8^tm1.2Avo
Targeted Allele Detail

Summary

• Symbol: Taf8^tm1.2Avo
• Name: TATA-box binding protein associated factor 8; targeted mutation 1.2, Anne K Voss
• MGI ID: MGI:7511861
• Gene: Taf8 Location: Chr17:47794289-47813216 bp, - strand Genetic Position: Chr17, 23.33 cM, cytoband C
• Alliance: Taf8^tm1.2Avo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:337771
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT-flanked neomycin resistance cassette and second loxP site were inserted downstream of exon 7. Exons 1-7 and the neomycin were removed via cre-mediated recombination in the germline. (J:337771)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Taf8 Mutation: 26 strains or lines available

References

• Original: J:337771 El-Saafin F, et al., Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death Differ. 2022 May;29(5):1013-1027
• All: 1 reference(s)