Sfmbt2^em1Ogu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sfmbt2^em1Ogu
• Name: Scm-like with four mbt domains 2; endonuclease-mediated mutation 1, Atsuo Ogura
• MGI ID: MGI:7511858
• Synonyms: Sfmbt2-CDS KO, Sfmbt2-coding sequence (CDS) KO
• Gene: Sfmbt2 Location: Chr2:10375321-10600064 bp, + strand Genetic Position: Chr2, 7.81 cM
• Alliance: Sfmbt2^em1Ogu page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 68,029 bp deletion encompassing exons 4-8. The Mirc57 microRNA cluster in intron 11 is present. (J:287305, J:324527)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sfmbt2 Mutation: 43 strains or lines available

References

• Original: J:287305 Inoue K, et al., Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas. Nat Commun. 2020 May 1;11(1):2150
• All: 3 reference(s)