Ash1l^tm1.1Hej
Targeted Allele Detail

Summary

• Symbol: Ash1l^tm1.1Hej
• Name: ASH1 like histone lysine methyltransferase; targeted mutation 1.1, Jin He
• MGI ID: MGI:7511829
• Synonyms: Ash1l^2f
• Gene: Ash1l Location: Chr3:88857929-88986682 bp, + strand Genetic Position: Chr3, 39.01 cM
• Alliance: Ash1l^tm1.1Hej page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314124
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted around exon 4 and an FRT flanked neo cassette was inserted via homologous recombination. Flp-mediated recombination removed the neo cassette. (J:314124)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ash1l Mutation: 138 strains or lines available

References

• Original: J:314124 Gao Y, et al., Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors. Commun Biol. 2021 Jun 18;4(1):756
• All: 2 reference(s)