Mmp14^tm1.1Pami
Targeted Allele Detail

Summary

• Symbol: Mmp14^tm1.1Pami
• Name: matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1.1, Paolo Mignatti
• MGI ID: MGI:7511770
• Synonyms: Mmp14^Y573D
• Gene: Mmp14 Location: Chr14:54669055-54679913 bp, + strand Genetic Position: Chr14, 27.79 cM
• Alliance: Mmp14^tm1.1Pami page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305628
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: Tyrosine codon 573 (TAC) in exon 10 was changed to aspartic acid (GAC) (p.Y573D) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 9. The neo cassette was removed through subsequent Cre-mediate recombination. The mutation changes the residue in the cytoplasmic tail of the encoded peptide from phosphorylatable to a phosphomimetic. (J:305628)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp14 Mutation: 42 strains or lines available

References

• Original: J:305628 Attur M, et al., Membrane-type 1 Matrix Metalloproteinase Modulates Tissue Homeostasis by a Non-proteolytic Mechanism. iScience. 2020 Dec 18;23(12):101789
• All: 2 reference(s)