Notch1^em2Rsh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Notch1^em2Rsh
• Name: notch 1; endonuclease-mediated mutation 2, Robert S Haltiwanger
• MGI ID: MGI:7511611
• Synonyms: Notch1^8f, Notch1^T311V
• Gene: Notch1 Location: Chr2:26347914-26393834 bp, - strand Genetic Position: Chr2, 18.91 cM
• Alliance: Notch1^em2Rsh page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated an ACC to GTG change at nt22681-22683 resulting in a threonine to valine substitution at amino acid 311 (p.T311V) in exon 6, resulting in a hypomorphic allele. (J:338825)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Notch1 Mutation: 115 strains or lines available

References

• Original: J:338825 LoPilato RK, et al., Two NOTCH1 O-fucose sites have opposing functions in mouse retinal angiogenesis. Glycobiology. 2023 Jun 17
• All: 1 reference(s)