Setd1a^em1Kano
Endonuclease-mediated Allele Detail

Summary

• Symbol: Setd1a^em1Kano
• Name: SET domain containing 1A; endonuclease-mediated mutation 1, Masanobu Kano
• MGI ID: MGI:7510020
• Gene: Setd1a Location: Chr7:127376561-127399294 bp, + strand Genetic Position: Chr7, 69.73 cM
• Alliance: Setd1a^em1Kano page

Mutation origin

• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a frame-shift mutation (deletion of 1133-1134) in the exon 7 of the gene. (J:298833)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setd1a Mutation: 56 strains or lines available

References

• Original: J:298833 Nagahama K, et al., Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities. Cell Rep. 2020 Sep 15;32(11):108126
• All: 2 reference(s)