Musk^em1Bali
Endonuclease-mediated Allele Detail

Summary

• Symbol: Musk^em1Bali
• Name: muscle, skeletal, receptor tyrosine kinase; endonuclease-mediated mutation 1, Baoming Li
• MGI ID: MGI:7507169
• Synonyms: MuSK-K608A, MuSK-kd
• Gene: Musk Location: Chr4:58285962-58374303 bp, + strand Genetic Position: Chr4, 31.87 cM
• Alliance: Musk^em1Bali page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Lysine codon 608 (AAG) in exon 13 was changed to alanine (GCA) (p.K608A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation renders the encoded peptide kinase-dead. (J:307970)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Musk Mutation: 42 strains or lines available

References

• Original: J:307970 Jing H, et al., Synapse-specific Lrp4 mRNA enrichment requires Lrp4/MuSK signaling, muscle activity and Wnt non-canonical pathway. Cell Biosci. 2021 Jun 5;11(1):105
• All: 1 reference(s)