Tardbp^tm1.1Wanx
Targeted Allele Detail

Summary

• Symbol: Tardbp^tm1.1Wanx
• Name: TAR DNA binding protein; targeted mutation 1.1, Xinglong Wang
• MGI ID: MGI:7506901
• Synonyms: TDPdeltaCR
• Gene: Tardbp Location: Chr4:148696839-148711476 bp, - strand Genetic Position: Chr4, 78.77 cM
• Alliance: Tardbp^tm1.1Wanx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:337808
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT flanked neo cassette was inserted in intron 4 and an alpha-helical region spanning residues from 321 to 340 was deleted from exon 6 via homologous recombination. Flp-mediated recombination removed the neo cassette. (J:337808)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tardbp Mutation: 83 strains or lines available

References

• Original: J:337808 Gao J, et al., Translational regulation in the brain by TDP-43 phase separation. J Cell Biol. 2021 Oct 4;220(10):e202101019
• All: 1 reference(s)