Psmc5^tm1.1Genp
Targeted Allele Detail

Summary

• Symbol: Psmc5^tm1.1Genp
• Name: protease (prosome, macropain) 26S subunit, ATPase 5; targeted mutation 1.1, Gentry N Patrick
• MGI ID: MGI:7506899
• Synonyms: Rpt6 S120D
• Gene: Psmc5 Location: Chr11:106147011-106153938 bp, + strand Genetic Position: Chr11, 68.89 cM, cytoband E1
• Alliance: Psmc5^tm1.1Genp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:308469
• Parent Cell Line: BAC-BA1 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S/SvEv)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Serine codon 120 (AGC) in exon 5 was changed to aspartic acid (GAC) (p.S120D) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 3. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation turns the affected residue in the encoded peptide from phosphorylatable to a phosphomimetic. (J:308469)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psmc5 Mutation: 33 strains or lines available

References

• Original: J:308469 Scudder SL, et al., Altered Phosphorylation of the Proteasome Subunit Rpt6 Has Minimal Impact on Synaptic Plasticity and Learning. eNeuro. 2021 May-Jun;8(3):ENEURO.0073-20.2021
• All: 1 reference(s)