Prox2^em1(flpo)Cbm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Prox2^em1(flpo)Cbm
• Name: prospero homeobox 2; endonuclease-mediated mutation 1, Carmen Birchmeier
• MGI ID: MGI:7506801
• Synonyms: Prox2^FlpO
• Gene: Prox2 Location: Chr12:85133159-85157533 bp, - strand Genetic Position: Chr12, 39.54 cM
• Alliance: Prox2^em1(flpo)Cbm page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Prox2^em1(flpo)Cbm expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Prox2 (MGI:1920672)

• Mutation details: Using CRISPR/Cas9 technology, a 1.5kb fragment containing the codon-optimized FLP recombinase (FlpO) and a bovine poly(A) sequence was inserted between the 5 UTR and 1st exon of the Prox2 gene by homology-directed repair. (J:337785)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Prox2 (mouse) Summary of all recombinase alleles driven by Prox2. Alliance mouse Prox2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prox2 Mutation: 19 strains or lines available

References

• Original: J:337785 Lowenstein ED, et al., Prox2 and Runx3 vagal sensory neurons regulate esophageal motility. Neuron. 2023 May 10
• All: 1 reference(s)