Cadm2^{tm1b(KOMP)Mbp}
Targeted Allele Detail

Summary

• Symbol: Cadm2^{tm1b(KOMP)Mbp}
• Name: cell adhesion molecule 2; targeted mutation 1b, Mouse Biology Program, UC Davis
• MGI ID: MGI:7506507
• Gene: Cadm2 Location: Chr16:66452307-67417796 bp, - strand Genetic Position: Chr16, 37.96 cM
• Alliance: Cadm2^{tm1b(KOMP)Mbp} page
• IMPC: Cadm2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:337782
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 66568963 of Chromosome 16 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 66569064. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:337782)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cadm2 Mutation: 37 strains or lines available

References

• Original: J:337782 Sanchez-Roige S, et al., CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice. Transl Psychiatry. 2023 May 12;13(1):167
• All: 1 reference(s)