Pdcd1^tm1.1Ozg
Targeted Allele Detail

Summary

• Symbol: Pdcd1^tm1.1Ozg
• Name: programmed cell death 1; targeted mutation 1.1, Ozgene
• MGI ID: MGI:7506386
• Synonyms: Pdcd1^flox
• Gene: Pdcd1 Location: Chr1:93966027-93980278 bp, - strand Genetic Position: Chr1, 47.47 cM
• Alliance: Pdcd1^tm1.1Ozg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:298172
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into introns 1 and 3, closely flanking exons 2 and 3. An Frt-PGK-NeoR-Frt selection cassette was placed immediately 5 of the LoxP site in intron 3. FLP-mediated recombination removed the selection cassette in the germline. (J:298172)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdcd1 Mutation: 48 strains or lines available

References

• Original: J:298172 Strauss L, et al., Targeted deletion of PD-1 in myeloid cells induces antitumor immunity. Sci Immunol. 2020 Jan 3;5(43)
• All: 4 reference(s)