Plxna1^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Plxna1^tm1.1Ics
• Name: plexin A1; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:7506324
• Synonyms: PlxnA1^Y1815F
• Gene: Plxna1 Location: Chr6:89293295-89339595 bp, - strand Genetic Position: Chr6, 39.91 cM, cytoband E2
• Alliance: Plxna1^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314102
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: Tyrosine codon 1815 in exon 31 (TAT) was changed to phenylalanine (TTT) (p.Y1815F) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 31. The neo cassette was removed through Cre-mediated recombination. The mutation prevents phosphorylation of the residue in the encoded peptide. (J:314102)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plxna1 Mutation: 73 strains or lines available

References

• Original: J:314102 Ducuing H, et al., SlitC-PlexinA1 mediates iterative inhibition for orderly passage of spinal commissural axons through the floor plate. Elife. 2020 Dec 21;9:e63205
• All: 1 reference(s)