Il18bp^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Il18bp^tm1.1Itl
• Name: interleukin 18 binding protein; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:7506187
• Synonyms: Il18bp^tm1iTL
• Gene: Il18bp Location: Chr7:101664092-101667897 bp, - strand Genetic Position: Chr7, 54.71 cM, cytoband F1
• Alliance: Il18bp^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:337716
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: A nuclear tdTomato reporter was inserted immediately upstream of the coding region in exon 3 of the gene. The reporter is followed by an A2 self-cleavable peptide, allowing independent production of the tdTomato and the IL-18BP proteins. An frt-flanked neomycin selection cassette was inserted into intron 7, then subsequently removed after selection via FLP-mediated recombination in the germline. (J:337716)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il18bp Mutation: 17 strains or lines available

References

• Original: J:337716 Harel M, et al., IL-18 Binding Protein-Producing Cells Attenuate Anemia in Murine Macrophage Activation Syndrome. J Immunol. 2023 Jun 1;210(11):1790-1803
• All: 2 reference(s)