Gt(ROSA)26Sor^{tm1.1(CAG-Mfsd2a)Chgu}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(CAG-Mfsd2a)Chgu}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Chenghua Gu
• MGI ID: MGI:7496063
• Synonyms: R26^LSL-Mfsd2a
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(CAG-Mfsd2a)Chgu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:293815
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(CAG-Mfsd2a)Chgu} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mfsd2a (MGI:1923824)

• Mutation details: The targeting construct contains from 5' to 3' a CAG-loxP-3xSV40PA Stop-loxP-mouse Mfsd2a cDNA-WPRE-bGH polyA-attB-PGK-neomycin-attP cassette. PhiC31-mediated recombination removed the neo cassette. (J:293815)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1084 strains or lines available

References

• Original: J:293815 Chow BW, et al., Caveolae in CNS arterioles mediate neurovascular coupling. Nature. 2020 Mar;579(7797):106-110
• All: 1 reference(s)