Ppp2r1a^tm1Bgh
Targeted Allele Detail

Summary

• Symbol: Ppp2r1a^tm1Bgh
• Name: protein phosphatase 2, regulatory subunit A, alpha; targeted mutation 1, Bernhard G Herrmann
• MGI ID: MGI:7495830
• Gene: Ppp2r1a Location: Chr17:21165716-21186167 bp, + strand Genetic Position: Chr17, 11.4 cM, cytoband A3.2
• Alliance: Ppp2r1a^tm1Bgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244157
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A construct (PRPGS00108_A_B03) was obtained from the KOMP repository and used for gene targeting. The construct is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site all inserted into intron 2. A third loxP site is inserted downstream of exon 2. (J:244157)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp2r1a Mutation: 41 strains or lines available

References

• Original: J:244157 Lange L, et al., Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a. Biol Open. 2017 Jun 15;6(6):752-764
• All: 1 reference(s)