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Rnaset2bem1Gaer
Endonuclease-mediated Allele Detail
Summary
Symbol: Rnaset2bem1Gaer
Name: ribonuclease T2B; endonuclease-mediated mutation 1, Jutta Gartner
MGI ID: MGI:7495613
Gene: Rnaset2b  Location: Chr17:7246259-7265592 bp, + strand  Genetic Position: Chr17, 4.57 cM
Alliance: Rnaset2bem1Gaer page
Mutation
origin
Strain of Origin:  C57BL/6N-Rnaset2atm1(KOMP)Wtsi
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Nucleotide substitutions
 
Mutation detailsCRISPR/Cas9 technology inserted a translational stop codon TAA and a BamHI restriction site in exon 2 (c.145_147delinsTAA, p.Pro49Ter). (J:315704)
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rnaset2b Mutation:  18 strains or lines available
References
Original:  J:315704 Kettwig M, et al., Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy. Nat Commun. 2021 Nov 11;12(1):6530
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory