Rnaset2b^em1Gaer
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rnaset2b^em1Gaer
• Name: ribonuclease T2B; endonuclease-mediated mutation 1, Jutta Gartner
• MGI ID: MGI:7495613
• Gene: Rnaset2b Location: Chr17:7246259-7265592 bp, + strand Genetic Position: Chr17, 4.57 cM
• Alliance: Rnaset2b^em1Gaer page

Mutation origin

• Strain of Origin: C57BL/6N-Rnaset2a^{tm1(KOMP)Wtsi}

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology inserted a translational stop codon TAA and a BamHI restriction site in exon 2 (c.145_147delinsTAA, p.Pro49Ter). (J:315704)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnaset2b Mutation: 18 strains or lines available

References

• Original: J:315704 Kettwig M, et al., Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy. Nat Commun. 2021 Nov 11;12(1):6530
• All: 1 reference(s)