Actl7a^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Actl7a^em1Osb
• Name: actin-like 7a; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:7495492
• Gene: Actl7a Location: Chr4:56743422-56744925 bp, + strand Genetic Position: Chr4, 31.66 cM
• Alliance: Actl7a^em1Osb page

Mutation origin

• Strain of Origin: C57BL6/N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 1306+2bp deletion of the single exon coding region encompassing 23bp upstream of the translational start site codon to 49bp upstream of the translational stop codon. (J:337424)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Actl7a Mutation: 19 strains or lines available

References

• Original: J:337424 Ferrer P, et al., Testis-specific actin-like 7A (ACTL7A) is an indispensable protein for subacrosomal-associated F-actin formation, acrosomal anchoring, and male fertility. Mol Hum Reprod. 2023 Feb 28;29(3)
• All: 1 reference(s)