Pkp2^tm1.1Mdel
Targeted Allele Detail

Summary

• Symbol: Pkp2^tm1.1Mdel
• Name: plakophilin 2; targeted mutation 1.1, Mario Delmar
• MGI ID: MGI:7495475
• Synonyms: PKP2^flox
• Gene: Pkp2 Location: Chr16:16031209-16090576 bp, + strand Genetic Position: Chr16, 10.09 cM, cytoband B1
• Alliance: Pkp2^tm1.1Mdel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247755
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Two forward loxP sites were inserted flanking exons 2 and 3, along with a downstream frt-flanked neomycin selection cassette. The frt-flanked neomycin selection cassette was removed in the germline via FLP-mediated recombination. (J:247755)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkp2 Mutation: 41 strains or lines available

References

• Original: J:247755 Cerrone M, et al., Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm. Nat Commun. 2017 Jul 24;8(1):106
• All: 6 reference(s)