Gcn1^em3Itohk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gcn1^em3Itohk
• Name: GCN1 activator of EIF2AK4; endonuclease-mediated mutation 3, Ken Itoh
• MGI ID: MGI:7494172
• Gene: Gcn1 Location: Chr5:115703313-115760713 bp, + strand Genetic Position: Chr5, 56.1 cM
• Alliance: Gcn1^em3Itohk page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR-cas9 mediated recombination using a donor vector resulted in the introduction of loxP sites around exon 2. (J:337230)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gcn1 Mutation: 137 strains or lines available

References

• Original: J:337230 Liu J, et al., Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage. Int J Mol Sci. 2022 Mar 16;23(6)
• All: 1 reference(s)