Gt(ROSA)26Sor^{em1(Slc1a3)Sjm}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(Slc1a3)Sjm}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Sean J Morrison
• MGI ID: MGI:7494114
• Synonyms: Rosa26^LSL-Glast
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(Slc1a3)Sjm} page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{em1(Slc1a3)Sjm} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Slc1a3 (MGI:99917)

• Gt(ROSA)26Sor^{em1(Slc1a3)Sjm} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gt(ROSA)26Sor (MGI:104735)

• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a loxp-Stop-loxp sequence followed by a mouse Glast coding sequence into the Gt(ROSA)26Sor locus. (J:337216)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1083 strains or lines available

References

• Original: J:337216 Qi L, et al., Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration. Cell Stem Cell. 2021 Nov 4;28(11):1982-1999.e8
• All: 1 reference(s)