Map3k8^em1Zgs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Map3k8^em1Zgs
• Name: mitogen-activated protein kinase kinase kinase 8; endonuclease-mediated mutation 1, Zhi-Gang She
• MGI ID: MGI:7492345
• Synonyms: TPL2^flox
• Gene: Map3k8 Location: Chr18:4331325-4352978 bp, - strand Genetic Position: Chr18, 2.73 cM
• Alliance: Map3k8^em1Zgs page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR/Cas9 technology was used to flank exon 4 with loxP sites. (J:336806)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k8 Mutation: 42 strains or lines available

References

• Original: J:336806 Gong J, et al., Tumor Progression Locus 2 in Hepatocytes Potentiates Both Liver and Systemic Metabolic Disorders in Mice. Hepatology. 2019 Feb;69(2):524-544
• All: 1 reference(s)