Por^tm1.1Jic
Targeted Allele Detail

Summary

• Symbol: Por^tm1.1Jic
• Name: cytochrome p450 oxidoreductase; targeted mutation 1.1, Central Institute for Experimental Animals, Japan
• MGI ID: MGI:7491799
• Synonyms: Por^Flox
• Gene: Por Location: Chr5:135698894-135764180 bp, + strand Genetic Position: Chr5, 75.34 cM, cytoband G1
• Alliance: Por^tm1.1Jic page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336704
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The Por exons 5-15 were flanked by FRT sequences by homologous recombination strategies using NOG-ES cells. The Puro drug-resistance marker gene was then removed from recombinant ES cells by transient expression of Cre recombinase. (J:336704)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Por Mutation: 80 strains or lines available

Notes

Embryonic stem cells (ES) NOG-ES was established and a clone a5363 was selected.

References

• Original: J:336704 Uehara S, et al., Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism. Sci Rep. 2022 Sep 1;12(1):14907
• All: 1 reference(s)