Gba1^tm1.1Shoy
Targeted Allele Detail

Summary

• Symbol: Gba1^tm1.1Shoy
• Name: glucosylceramidase beta 1; targeted mutation 1.1, Sho Yamasaki
• MGI ID: MGI:7491746
• Synonyms: Gba^flox
• Gene: Gba1 Location: Chr3:89110235-89116273 bp, + strand Genetic Position: Chr3, 39.01 cM
• Alliance: Gba1^tm1.1Shoy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336297
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 8 and a second loxP site and FRT-flanked neomycin resistance cassette were inserted downstream of exon 9. The neomycin resistance cassette was removed via flp-mediated recombination leaving exons 8-9 floxed. (J:336297)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gba1 Mutation: 46 strains or lines available

References

• Original: J:336297 Shimizu T, et al., Direct activation of microglia by beta-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease. Immunity. 2023 Feb 14;56(2):307-319.e8
• All: 1 reference(s)