Gt(ROSA)26Sor^{tm1(Hnf4a_i2)Vda}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Hnf4a_i2)Vda}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Valentin David
• MGI ID: MGI:7491659
• Synonyms: Hnf4a2^STOP, Hnf4alpha2^STOP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Hnf4a_i2)Vda} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336552
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Hnf4a_i2)Vda} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hnf4a (MGI:109128)	Expresses isoform 2

• A loxP-flanked STOP cassette and isoform 2 of Hnf4a (Hnf4a2) were inserted into the locus. (J:336552)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1083 strains or lines available

References

• Original: J:336552 Martinez-Calle M, et al., Transcription factor HNF4alpha2 promotes osteogenesis and prevents bone abnormalities in mice with renal osteodystrophy. J Clin Invest. 2023 Jun 1;133(11)
• All: 1 reference(s)