Ntrk1^em3Tkato
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ntrk1^em3Tkato
• Name: neurotrophic tyrosine kinase, receptor, type 1; endonuclease-mediated mutation 3, Tadafumi Kato
• MGI ID: MGI:7490183
• Gene: Ntrk1 Location: Chr3:87685551-87702469 bp, - strand Genetic Position: Chr3, 38.62 cM
• Alliance: Ntrk1^em3Tkato page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 12 deleted 1bp, resulting in frame-shift with premature termination. (J:309176)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntrk1 Mutation: 60 strains or lines available

References

• Original: J:309176 Nakajima K, et al., Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice. Transl Psychiatry. 2020 Nov 24;10(1):407
• All: 1 reference(s)