Tlr3^tm1Hlz
Targeted Allele Detail

Summary

• Symbol: Tlr3^tm1Hlz
• Name: toll-like receptor 3; targeted mutation 1, Bernhard Holzmann
• MGI ID: MGI:7490108
• Synonyms: TLR3^OFF
• Gene: Tlr3 Location: Chr8:45848702-45864112 bp, - strand Genetic Position: Chr8, 25.31 cM, cytoband B2
• Alliance: Tlr3^tm1Hlz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304220
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed transcriptional termination element was inserted between exons 3 and 4 of the gene. A lack of TLR3 protein expression was shown in bone marrow-derived macrophages generated from homozygous mice. If cre-mediated recombination occurs, normal expression of the gene is restored. (J:304220)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr3 Mutation: 66 strains or lines available

References

• Original: J:304220 Stoss C, et al., TLR3 promotes hepatocyte proliferation after partial hepatectomy by stimulating uPA expression and the release of tissue-bound HGF. FASEB J. 2020 Aug;34(8):10387-10397
• All: 3 reference(s)