Ptgs2^tm1.1Flv
Targeted Allele Detail

Summary

• Symbol: Ptgs2^tm1.1Flv
• Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1.1, Richard Flavell
• MGI ID: MGI:7489742
• Synonyms: Ptgs2^LSL
• Gene: Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
• Alliance: Ptgs2^tm1.1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297217
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Two loxP sites flanking a STOP cassette sequence and a frt-flanked PKG-neomycin cassette were inserted into intron 3. The frt-flanked PKG-neomycin cassette was removed via FLP-mediated recombination in the germline. (J:297217)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgs2 Mutation: 68 strains or lines available

References

• Original: J:297217 Roulis M, et al., Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche. Nature. 2020 Apr;580(7804):524-529
• All: 1 reference(s)